Translational Medicine (Track)
Cord blood cells (CBC) in the treatment of children brain trauma
Zhanna Borisovna Semenova Department Of Neurosurgery
Institute Of Urgent Surgery And Traumatology For Children
Moscow, Russia
Finland
Abstract:
Aim of the study was investigation of safety and efficacy of CBC intravenous infusion to 6 patients (3-16 years) with severe consequences after brain trauma. Duration of observations was 6 months after infusion of 250 х 106 allogeneic ABO/Rh+identical, RBC-depleted human CBC. Neurological, neuroophtalmological, otoneurological examination, neurophysiological checks, brain MRI and biochemical parameters of blood were monitored. During observation period all patients remained GOS 3. Nevertheless, positive changes in the restoration of motor and cognitive functions were evident. MRI spectroscopy showed significant elevation of NAA in cortex and temporal lobe after cell infusion. In 4 patients EEG monitoring revealed rhythmic activity in caudal zones. In 3 patients there was normalization of generated acoustic stem potentials. The improvement in cortex component of acoustic response was also registered in 3 patients. Elevated level of serum BDNF was seen after cell infusion. Neuroprotective and trophic nature of CBC effects is supported by positive clinical dynamics and by results of instrumental examination.
